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Nanoparticle science/technology

Validation of Gold Nanoparticle DNA-based Biosensors for the Detection of Non-PCR Amplified Bacterial Food Borne Pathogens in Food Matrices

Principal Investigator: 
Sylvia Vetrone
Since the intentional distribution of Bacillus anthracis spores through the US postal system in 2001, the prospect of bioterrorism in food, water, and agriculture has identified critical needs in prevention, protection, and mitigation for homeland security. Towards that end, we recently...

Advancing SERS to field technology for food defense application

Principal Investigator: 
Lili He
The use of biological and chemical toxins as terror agents on the food supply could cause catastrophic consequences to public health and severe economic impact. However, an analytical method that can rapidly detect these agents in dynamic food chains is lacking. Previously, we received NCFPD...

Development of a Multiplex Bio-barcode DNA Biosensor for Bacillus anthracis Phase II

Principal Investigator: 
Evangelyn Alocilja
The long-term goal of the above project is to develop a DNA-based detection device that will not require PCR amplification and still retain PCRsensitivity. For this particular project, the deliverables include: (1) Synthesis and characterization of the DNA probe-coated and bio-barcoded...

Application of Surface Enhanced Raman Spectroscopy in Detection of Chemical and Biological Terror Agents in Food Matrices II

Principal Investigator: 
Theodore Labuza
The objectives of this continuing project are to apply, improve, and validate developed SERS immunoassays to detect real ricin and anthrax spores in milk, Both antibody and aptamer will be used as capturers. The DNA aptamer is expected to give more distinct SERS patterns compared with protein...

Validation and optimization of biologically modified electrically-active magnetic nanoparticles (nano-BEAMs) for direct capture and concentration of bioterrorism agents in various food matrices

Principal Investigator: 
Evangelyn Alocilja
The existing project focuses on the synthesis and novel application of biologically modified electrically-active magnetic nanoparticles (nano-BEAMs) for sample acquisition and pre-analytical processing to render representative samples of food products ready for rapid agent detection in multiple...

Proof-of-concept study for the development of a cell-free GPCR-based biosensor for rapid non-specific detection of chemical and biological toxic agents

Principal Investigator: 
Evangelyn Alocilja
This project is a high-risk/high-reward exploratory proof-of-concept work to evaluate the potential of G-protein coupled receptors (GPCRs) as sensing elements in biosensor devices for rapid non-specific but highly sensitive detection (detect-to-warn) of toxicants in selected complex food matrices...

Application of Surface Enhanced Raman Spectroscopy for Detection of Chemical and Biological Terror Agents in Food Matrices

Principal Investigator: 
Theodore Labuza
Rapid, sensitive, and accurate detection of chemical and biological terror agents is of critical importance to monitor and prevent bioterrorism events. Conventional chromatographic techniques for chemical detection and culture techniques for bio-agent detection face serious limitations, especially...

Development of Biologically Modified Electrically-active Magnetic Nanoparticles (nano-BEAMS) for Direct Capture and Concentration of Bacillus anthracis Spores and Cells in Various Food Matrices

Principal Investigator: 
Evangelyn Alocilja
This project has 4 objectives, namely: (1) to synthesize and characterize electrically-active magnetic nanoparticles, (2) to biologically modify the nanoparticles (nano-BEAMs) with antibodies and aptamers specific to the target Bacillus anthracis and optimize the binding parameters, (3) to evaluate...
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