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Biological Threats and Countermeasures

Validation of Gold Nanoparticle DNA-based Biosensors for the Detection of Non-PCR Amplified Bacterial Food Borne Pathogens in Food Matrices

Principal Investigator: 
Sylvia Vetrone
Since the intentional distribution of Bacillus anthracis spores through the US postal system in 2001, the prospect of bioterrorism in food, water, and agriculture has identified critical needs in prevention, protection, and mitigation for homeland security. Towards that end, we recently...

Vulnerability Assessment of Critical Food Additives

Principal Investigator: 
Margaret Rush
The overall objective of this study is to assess vulnerability of the food supply to introduction of a chemical or biological contaminant through a food additive. To our knowledge, no group has performed a vulnerability assessment that considers the intentional contamination of food additives. The...

Development of a Quantitative Food Supply Vulnerability Tool Exploring Public Health Risks

Principal Investigator: 
Emma Hartnett
The FSMA (2011) Section 106 requires that a vulnerability assessment of the food system be conducted, including biological, chemical, radiological, or other risk assessments. While defining vulnerability, DHS (2010) noted that a practical measure is the "likelihood that an attack is successful...

Frontier Interdisciplinary eXperiences (FIX) Coordinators for NCFPD Career Development Program

Principal Investigator: 
Justin Kastner; Jason Ackleson
The Frontier program and its flagship educational and mentorship effort the FIX program illustrate an inter-university approach to preparing undergraduate and graduate students for tomorrow's complex, multi-faceted Homeland Security challenges. Hallmarks of the FIX program include genuine...

Development of a Multiplex Bio-barcode DNA Biosensor for Bacillus anthracis Phase II

Principal Investigator: 
Evangelyn Alocilja
The long-term goal of the above project is to develop a DNA-based detection device that will not require PCR amplification and still retain PCRsensitivity. For this particular project, the deliverables include: (1) Synthesis and characterization of the DNA probe-coated and bio-barcoded...

Modification of Sample Preparation to Differentiate Live, Injured and Dead Bacteria in Polymerase Chain Reaction Assay

Principal Investigator: 
Teshome Yehualaeshet
Accurate determination of live, damaged or injured, and dead bacteria is important in microbiology detection to avoid false alarm. Dead bacteria present after processes such as pasteurization or disinfection might present no hazard but still can be detected by Polymerase chain reaction (PCR)...

On-Site Detection of Microbial Pathogens and Chemical Toxic Agents Using Novel Sensors Based on Quantum Dot Modified Molecular Imprinted Polymers

Principal Investigator: 
Keith Warriner
On-site diagnostic tools are an essential part of emergency management given that early detection of the hazard leads to rapid containment and corrective action. However, current diagnostic devices for on-site testing are lacking, expensive or require multiple step protocols and technical expertise...

Validation of Agent Inactivation and Isolation from Food Systems

Principal Investigator: 
Alvin Lee
Validation of a process needed to eliminate a microbiological or chemical hazard in food can be difficult. Processing technologies that have shown efficacy in eliminating a hazard under laboratory conditions, usually under well controlled parameters, may not be effective against the threat agent...


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