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Biological Threats and Countermeasures

Extraction and Concentration of Chemical (Tetramethylenedisulfotetramine) and biological (ricin) toxins using Molecular Imprinted Electrospun Fibers Coupled with Detection at Aptamer Modified Polymer Electrodes

Principal Investigator: 
Keith Warriner
On-site screening of biohazards is an essential tool to contain or prevent dissemination of toxic agents within the food chain. Although there are highly sensitive laboratory based systems available for biohazard detection the majority require a high degree of technical expertise and cannot be...

Thermal and Chemical Inactivation of Select Agent Toxins in Liquid Foods

Principal Investigator: 
Francisco Diez-Gonzalez
The overall goal of this project is to characterize the thermal and chemical stability of selected toxins in milk and juices and to investigate the conditions for their rapid inactivation. The specific goals of this project are: 1. Characterize the thermal stability of ricin, abrin, staphylococcal...

Conversion of the Academic CMS to a Web-Enabled Version for Academic Use

Principal Investigator: 
Susan Harlander
There is significant concern about the ability of government and industry to efficiently and effectively recognize and respond to intentional bioterrorist attacks on the food supply that could result in catastrophic economic or human health consequences. The systems employed for safeguarding the...

Extraction of Bacillus anthracis Spores and Ricin from Liquid Foods and its Potential Utilization for Inline Detection

Principal Investigator: 
Francisco Diez-Gonzalez
The major objectives of this project are to identify a method for efficient extraction and concentration of Bacillus anthracis spores and ricin toxin from milk and orange juice, and to identify compatible rapid detection technologies. In addition to the major project objectives, a method for PCR...

Validation of Methods for Decontamination of Food Processing Equipment and Facilities

Principal Investigator: 
Alvin Lee
The goal of this project is to validate the effects of various cleaning and liquid/gaseous sanitizing protocols for decontamination of food processing equipment and facilities with spores of several potential surrogate Bacillus species including B. anthracis Sterne strains, with validation under...

Identification and Characterization of Temperature-dependent Virulent Genes in Y. pestis, .Y pseudotuberculosis and Y. enterocolitica.

Principal Investigator: 
Teshome Yehualaeshet
Important pathogens in the genus Yersinia include the plague Yersinia pestis and two enteropathogenic species, Yersinia pseudotuberculosis and Yersinia enterocolitica. Y. pestis is a potential agent as a terrorist weapon, either in a covert or overt manner. Y. pestis and Y. pseudotuberculosis share...

Stability of Botulinum Neurotoxin (BoNT) in Food Matrices

Principal Investigator: 
Eric Johnson
The traditionally safe U.S. food supply may be an attractive target for bioterrorists intent on causing large numbers of casualties, or with the intention of creating nationwide panic about the safety of foods. Deliberate contamination of food or beverages may be the most likely route of botulinum...

Modeling the Public Health System Response to a Terrorist Event

Principal Investigator: 
Don Schaffner
The objective of this project was to conduct simulation modeling of the public health system, specifically focusing on the detection of deliberate food contamination events by the public health system, and the response of that system to such events. The simulation model can be used to evaluate the...


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