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Biological Threats and Countermeasures

Use of Plasma Technology to Decontaminate Surfaces and Air in Food Processing Environments

Principal Investigator: 
Amy Wong
The overall goal of the proposed research is to use plasma-aided technologies to disinfect surfaces and air in food processing environments that have been contaminated with Bacillus cereus spores, a surrogate for Bacillus anthracis. This proposal specifically addresses Aim D.1.2 "Test specific...

Extraction, Concentration, and Detection of Toxins in Solid Food Systems using Molecular Imprinted Polymer Films

Principal Investigator: 
Keith Warriner
An integrated system to extract, concentrate and detect Staphylococcus aureus exterotoxin B (SEB) has been developed. The main focus of the work was to deliver a robust, low cost system that could be automated to permit on-site toxin screening capabilities. Since biological affinity agents are...

Evaluation of Methods for Decontamination of Food Processing Equipment and Facilities Deliberately Contaminated with Bacillus Spores

Principal Investigator: 
Martin Cole
To validate the effects of various cleaning and liquid/gaseous sanitizing protocols for decontamination of food processing equipment and facilities with spores of several potential surrogate Bacillus species including B. anthracis Sterne strains, with validation under controlled conditions using B...

Concentrating Bacterial Spores from Milk and Juices using Dielectrophoresis-Based Microfluidic Capture Systems

Principal Investigator: 
Suresh Pillai
A microscale prototype device that can be ultimately scaled up for concentrating bacterial spores from large volumes of milk and apple juice is developed. Dielectrophoresis (DEP) is utilized to concentrate Clostridium sporogenes as surrogates of Bacillus anthracis and Clostridium botulinum spores...

Heat Inactivation Kinetics of Spores and Toxins in Liquid Milk

Principal Investigator: 
Theodore Labuza
The goal of this project was the development of an easy to achieve thermal process (with or without added biocides) capable of inactivating B. anthracis spores and ricin in intentionally adulterated foods so as to dispose of them to minimize their release to the environment. In the event of a...

Micro/Nano Technology for Botulinum Neurotoxin Sensing in the Food Supply

Principal Investigator: 
Eric Johnson
The overall goals of this project were to develop sensitive and specific micro-scale detection systems for botulinum neurotoxin (BoNT) that can be used to detect BoNT in intentionally adulterated foods or other samples and quickly communicate detection events using wireless technology. Additionally...

Public Health Investigation of Multistate Foodborne Outbreaks

Principal Investigator: 
Craig Hedberg
Purpose: These CIFOR multi-jurisdictional guidelines are intended to help improve communication and coordination between agencies investigating multi-jurisdictional outbreaks at all levels of governmental organization. The guidelines are proposed to help agencies identify multijurisdictional...

Bioluminescent Imaging for High Throughput Screening for Bacterial Pathogens and Toxins

Principal Investigator: 
Mansel Griffiths
The goal of the project is to develop cell-based bioluminescent biosensor for pathogenicity. The following objectives were planned: 1. Amass a collection of bioluminescent bacteria, both pathogenic and non-pathogenic, and investigate their attachment to mammalian cell monolayers, and to...

Hydrophobic Extraction of B. anthracis Spores from Liquid Foods

Principal Investigator: 
Francisco Diez-Gonzalez
The lack of effective pre-analytical methods for quick recovery of select agents in foods is a major weakness of our national food security system. Milk and other liquid foods that are potential targets for bio-terrorist attack with a number of select agents, including Bacillus anthracis. The...


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