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Application of Surface Enhanced Raman Spectroscopy in Detection of Chemical and Biological Terror Agents in Food Matrices II

Award No.: 
Principal Investigator: 
Theodore Labuza
PI Organization: 
University of Minnesota-Twin Cities
The objectives of this continuing project are to apply, improve, and validate developed SERS immunoassays to detect real ricin and anthrax spores in milk, Both antibody and aptamer will be used as capturers. The DNA aptamer is expected to give more distinct SERS patterns compared with protein antibody and antigen, providing a more sensitive way of detection. Both PCA and PLS will be applied for qualitative and quantitative analysis. Another objective is to test the feasibility of using a portable Raman instrument in SERS immunoassays. It is expected that the SERS immunoassays based on a portable Raman instrument will be rapid, cost-effective, and fiedable in detection of bioweapons in complex food matrices.
Analytic Methods Utilized: