University of Wisconsin-Madison
The overall goals of this project were to develop sensitive and specific micro-scale detection systems for botulinum neurotoxin (BoNT) that can be used to detect BoNT in intentionally adulterated foods or other samples and quickly communicate detection events using wireless technology. Additionally, the liquid crystal sensing component of the system lends itself to integration with food packaging to provide visual indicators of contamination. By developing and merging two sensing methods, (a) biomembrane sensing and bio-electronic transduction and (b) liquid crystal-based sensors, this project has involved into an integrated, wireless, modular platform for sensing botulinum toxin (BoNT). During this project, our laboratories successfully carried out a multidisciplinary collaboration to develop sensing platforms for botulinum neurotoxins (BoNTs) based on microfluidics and liquid sensor platforms. Wireless and optical sensing for biological toxins was also a method developed in this the project.